2016 Mercedes-Benz E-Class fuel economy
The 2016 Mercedes-Benz E-Class is rated at 18–23 MPG combined by the EPA, from 18 MPG (5.5 L 8-cyl turbo, Automatic 7-spd, 4-Wheel Drive) to 23 MPG (3.5 L 6-cyl, Automatic 7-spd, Rear-Wheel Drive). EPA size class: Midsize Cars, Subcompact Cars, Midsize Station Wagons.
MPG by version
| Version | City | Hwy | Comb. | L/100 km | UK MPG | Fuel cost/yr* |
|---|---|---|---|---|---|---|
| E350 3.5 L 6-cyl, Automatic 7-spd, Rear-Wheel Drive · Premium Gasoline | 20 | 28 | 23 | 10.2 | 28 | $3,550 |
| E350 3.5 L 6-cyl, Automatic 7-spd, Rear-Wheel Drive · Flex-fuel · Premium Gasoline | 20 | 29 | 23 | 10.2 | 28 | $3,550 |
| E350 4matic 3.5 L 6-cyl, Automatic 7-spd, 4-Wheel Drive · Premium Gasoline | 20 | 27 | 23 | 10.2 | 28 | $3,550 |
| E350 4matic 3.5 L 6-cyl, Automatic 7-spd, 4-Wheel Drive · Flex-fuel · Premium Gasoline | 20 | 27 | 23 | 10.2 | 28 | $3,550 |
| E400 3.0 L 6-cyl turbo, Automatic 7-spd, Rear-Wheel Drive · Premium Gasoline | 20 | 29 | 23 | 10.2 | 28 | $3,550 |
| E400 4matic Coupe 3.0 L 6-cyl turbo, Automatic 7-spd, 4-Wheel Drive · Premium Gasoline | 20 | 28 | 23 | 10.2 | 28 | $3,550 |
| E400 Convertible 3.0 L 6-cyl turbo, Automatic 7-spd, Rear-Wheel Drive · Premium Gasoline | 20 | 29 | 23 | 10.2 | 28 | $3,550 |
| E400 Coupe 3.0 L 6-cyl turbo, Automatic 7-spd, Rear-Wheel Drive · Premium Gasoline | 20 | 29 | 23 | 10.2 | 28 | $3,550 |
| E350 4matic (wagon) 3.5 L 6-cyl, Automatic 7-spd, 4-Wheel Drive · Premium Gasoline | 20 | 26 | 22 | 10.7 | 26 | $3,750 |
| E400 4matic 3.0 L 6-cyl turbo, Automatic 7-spd, 4-Wheel Drive · Premium Gasoline | 20 | 27 | 22 | 10.7 | 26 | $3,750 |
| E550 4matic 4.7 L 8-cyl turbo, Automatic 7-spd, 4-Wheel Drive · Premium Gasoline | 18 | 24 | 21 | 11.2 | 25 | $3,900 |
| E550 Coupe 4.7 L 8-cyl turbo, Automatic 7-spd, Rear-Wheel Drive · Premium Gasoline | 18 | 26 | 21 | 11.2 | 25 | $3,900 |
| E550 Convertible 4.7 L 8-cyl turbo, Automatic 7-spd, Rear-Wheel Drive · Premium Gasoline | 17 | 25 | 20 | 11.8 | 24 | $4,100 |
| AMG E63 4matic 5.5 L 8-cyl turbo, Automatic 7-spd, 4-Wheel Drive · Premium Gasoline | 16 | 23 | 19 | 12.4 | 23 | $4,350 |
| AMG E63 S 4matic 5.5 L 8-cyl turbo, Automatic 7-spd, 4-Wheel Drive · Premium Gasoline | 15 | 22 | 18 | 13.1 | 22 | $4,550 |
| AMG E63 S 4matic (wagon) 5.5 L 8-cyl turbo, Automatic 7-spd, 4-Wheel Drive · Premium Gasoline | 16 | 21 | 18 | 13.1 | 22 | $4,550 |
* EPA estimate of yearly fuel (or electricity) cost for 15,000 miles with 55 % city driving, at the fuel prices EPA used for this model year. Use the fuel cost comparison with your own mileage and prices.
About these numbers
EPA ratings come from standard laboratory tests adjusted to reflect real-world driving, so they are best for comparing vehicles. Your own figure will vary with speed, temperature, load, tires and driving style — measure it with the MPG calculator. If you have fitted larger tires, correct the reading with the tire size and fuel economy calculator.
Source: U.S. Environmental Protection Agency and U.S. Department of Energy, fueleconomy.gov. Original data (downloaded 2026-09-29). Data processed by us; errors in processing are ours, not the publisher's.